Literature

1. Horie, F., Endo, K.*, and Ito, K.*: "Artificial protein-responsive riboswitches upregulate non-AUG translation initiation in yeast." ACS Synthetic Biology, 9 (7): 1623-1631 (2020). [DOI]
2. Endo, K.*, Hayashi, K., and Saito, H.*: "Numerical operations in living cells by programmable RNA devices." Science Advances, 5 (8): eaxx0835 (2019).[DOI]
3. Wroblewska, L., Kitada, T.‡,. Endo, K.‡, Siciliano, V., Stillo, B., Saito, H., and Weiss, R.: "Mammalian synthetic circuits with RNA binding proteins for RNA-only delivery ." Nature Biotechnology, 33 (8): 839-841 (2015). [DOI]
4. Miki, K.‡,. Endo, K.‡, Takahashi, S., Funakoshi, S., Takei, I., Katayama, S., Toyoda, T., Kotaka, M., Takaki, T., Umeda, M., Okubo, C., Nishikawa, M., Oishi, A., Narita, M,. Miyashita, I., Asano, K., Hayashi, K., Osafune, K., Yamanaka, S., Saito, H., and Yoshida, Y.: "Efficient detection and purification of cell populations by synthetic microRNA switches. Cell Stem Cell, 16 (6): 699-711 (2015). [DOI]
5. Endo, K., Hayashi, K., Inoue, T., and Saito, H.: "A versatile cis-acting inverter module for synthetic translational switches. Nature Communications, 4: 2393 (2013).[DOI]

Future Plan

Focusing on the functions of RNA-protein complexes, we will engage in research to create new biotechnologies that will lead to gene therapy and other applications through the engineering of these molecules and complexes. Furthermore, we will challenge the implementation of the created technologies in society. In addition, we aim to uncover previously overlooked wonders of life and elucidate them through research that seeks to assemble and apply existing knowledge.

Messages to Students

Scientific understanding of life is advancing at a remarkable rate. Let us challenge you to explore a new world while making the most of the knowledge we have accumulated so far!

URL

https://sites.google.com/edu.k.u-tokyo.ac.jp/molgenet/home