Highlights

・Lymphoma transcriptome is under control of global H3K27me3 accumulation

・EZH1 and EZH2 are druggable targets in EZH2WT/WT and EZH2WT/Mu malignancies

・Inactivation of chromatin-associated genes triggers EZH1/2 perturbation

・Targeting epigenome for pre-cancerous states is achieved by EZH1/2 inhibition

Papers

Makoto Yamagishi*, Makoto Hori, Dai Fujikawa, Takeo Ohsugi, Daisuke Honma, Nobuaki Adachi, Harutaka Katano, Tsunekazu Hishima, Seiichiro Kobayashi, Kazumi Nakano, Makoto Nakashima, Masako Iwanaga, Atae Utsunomiya, Yuetsu Tanaka, Seiji Okada, Kunihiro Tsukasaki, Kensei Tobinai, Kazushi Araki, Toshiki Watanabe, Kaoru Uchimaru*,"Targeting Excessive EZH1 and EZH2 Activities for Abnormal Histone Methylation and Transcription Network in Malignant Lymphomas",Cell Reports,10.1016/j.celrep.2019.10.083