INTRODUCTION OF LABORATORY

On the basis of advanced materials science, we are developing the technology needed to achieve new science. Our projects are observing dynamics in biological physics, soft-matter, and nano-materials systems. We are creating a very large super-transdisciplinary area by using these sample systems. Recently, we succeeded in time-resolved (-μs) x-ray observations of dynamical motions of individual functional protein channels in aqueous solutions for the first time of the world. In this single molecular detection system, which we call diffracted x-ray tracking (DXT), we observed the rotating motions of an individual nanocrystal, which is labeled to a specific site in individual functional molecules, using time-resolved Laue diffraction. New features of the mechanism of functional biological molecules were found in the above study, and we are considering many applications, for example, X-ray trapping, X-ray evanescent microscope, and Single molecular detection system using electron probe. To achieve the acquisition of advanced information in super-transdisciplinary science, we hope to contribute to material sciences, life sciences, nanotechnology, and biotechnology. Especially, monitoring internal molecular motions and dynamical localization will be particularly important in the future science. Additionally, we should consider user-friendliness and availability to researchers and developers. We will demonstrate the potential of new measurements by using new advanced light sources. For education, our goal is bringing up students who can conduct scientific research and contribute to practical developments. Now, it is very important for scientists to develop this new super-transdisciplinary science.

x線1分子計測法の原理。対象は生体分子からナノ無機構造体まで可能。

DNA1分子高精度運動観察。チャネルタンパク質の内部運動計測。フィラメント分子の2方向運動計測。1Å精度以下の1分子運動計測。～aNX線放射圧の計測。運動のシミュレーション。1分子抗原抗体反応ダイナミクス。測定されたサンプル系の例。

解析スポット（白線）の連続撮影。撮影時間はミリ秒。解析情報の運動を世界で初めて捕らえた瞬間（下円形はX線ストッパーの形）。