The formation of interstitial spaces in cancer tissues acts as a barrier to the use of DDS drugs, and although they work in animal models, they do not work in humans. We focused on insoluble fibrin, which is a major component of the cancer stroma, and established antibodies that recognize only insoluble fibrin and do not recognize fibrinogen or FDP, and produced antibody drug conjugates. In addition, we have developed a novel therapy called cancer stromal targeting (CAST). In addition, we have discovered a novel colorectal cancer-specific molecule, TMEM180, by a special method and will discuss the possibility of cancer stem cell targeting therapy using this antibody.

This presentation will outline the state of the world's most frequent disasters, which are expected to worsen with climate change, and how they are hindering the growth of developing countries. Affected people are concentrated in developing countries. Among them, groups such as the poor and women are particularly vulnerable. We will also consider how Japan's technology and experience can be useful for disaster reduction in the world.

The control of intermolecular interactions results in the synthesis of supramolecules, such as molecular machines, that have functions not found in single molecules. Supramolecular chemistry has been developed mainly as a science of solutions, but has recently been applied to the design of various materials ranging from gels and rubbers to resins. In this seminar, we will introduce a supramolecular plastic made from a molecular machine called rotaxane.